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12) Ockene JK, Barad DH, Cochrane BB, et al. Symptom experience after discontinuing use of estrogen plus progestin. JAMA. 2005;294:183‒93〔PMID:16014592〕(レベルⅢ) 13) de Klerk BM, Schiphof D, Groeneveld FP, et al. Limited evidence for a protective effect of unopposed oestrogen therapy for osteoarthritis of the hip:a systematic review. Rheumatology(Oxford). 2009;48:104‒12〔PMID:19000994〕(レベルⅠ) 14) Williams JAE, Chester‒Jones M, Minns Lowe C, et al. Hormone replacement therapy(conjugated oestrogens plus bazedox-ifene)for post‒menopausal women with symptomatic hand osteoarthritis:primary report from the HOPE‒e randomised, placebo‒controlled, feasibility study. Lancet Rheumatol. 2022;4:e725‒e737〔PMID:36341025〕(レベルⅡ) 15) Watt FE. Hand osteoarthritis, menopause and menopausal hormone therapy. Maturitas. 2016;83:13‒8〔PMID:26471929〕(review)104  CQ101 関節痛に対しHRTは有効か?

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