20427T

5/12

CQ 9　35 2） Hara H, Kadowaki S, Asayama M, et al. First-line bolus 5-fluorouracil plus leucovorin for peritoneally disseminated gastric cancer with massive ascites or inadequate oral intake. Int J Clin Oncol. 2018; 23: 275-80. 3） Iwasa S, Goto M, Yasui H, et al. Multicenter feasibility study of combination therapy with fluorouracil, leucovorin and paclitaxel (FLTAX) for peritoneal disseminated gastric cancer with massive ascites or inadequate oral intake. Jpn J Clin Oncol. 2012; 42: 787-93. 4） Nakajima TE, Yamaguchi K, Boku N, et al. Randomized phase II/III study of 5-fluorouracil/l-leucovo-rin versus 5-fluorouracil/l-leucovorin plus paclitaxel administered to patients with severe peritoneal metastases of gastric cancer (JCOG1108/WJOG7312G). Gastric Cancer. 2020; 23: 677-88. 5） Masuishi T, Kadowaki S, Kondo M, et al. FOLFOX as First-line Therapy for Gastric Cancer with Se-vere Peritoneal Metastasis. Anticancer Res. 2017; 37: 7037-42. 6） Osumi H, Takahari D, Chin K, et al. Modified FOLFOX6 as a first-line treatment for patients with advanced gastric cancer with massive ascites or inadequate oral intake. Onco Targets Ther. 2018; 11: 8301-8. 7） Oh SY, Kwon HC, Lee S, et al. A Phase II study of oxaliplatin with low-dose leucovorin and bolus and continuous infusion 5-fluorouracil （modified FOLFOX-4） for gastric cancer patients with malignant ascites. Jpn J Clin Oncol. 2007; 37: 930-5. 8） Masuishi T, Nakajima TE, Yamazaki K, et al. WJOG10517G: a multicenter Phase II study of mFOLF-OX6 in gastric cancer patients with severe peritoneal metastases. Future Oncol. 2020; 16: 1417-24.引用・参考文献 1） Shirao K, Boku N, Yamada Y, et al.; Gastrointestinal Oncology Study Group of the Japan Clinical On-cology Group. Randomized Phase III study of 5-fluorouracil continuous infusion vs. sequential metho-trexate and 5-fluorouracil therapy in far advanced gastric cancer with peritoneal metastasis (JCOG0106). Jpn J Clin Oncol. 2013; 43: 972-80.が行われている（WJOG10517G）8）。 明日への提言高度腹膜転移による経口摂取不能または大量腹水を伴う胃癌では，PS不良例が多く，通常のがん薬物療法では限界がある。FOLFOX療法の導入がかかる対象の光明となるか。さらに，腹腔内投与など新たなアプローチにも期待がかかる。 検索資料・参考にした二次資料データベース：PubMed　期間：2000-2020　keyword・件数：gastric cancer，perito-neal metastasis，chemotherapy，not intraperitoneal chemotherapy　784件　Filters ac-tivated：Clinical Trial，Meta-analysis，Randomized controlled trial，English.　74件。そのうち本CQに関連ありと判断されたのは4件。文献5-7は担当者判断で追加した。